Abstract 1681: Genetic ancestry distribution in basal-cell carcinoma cases and controls from Puerto Rico

Abstract

Abstract Introduction: The incidence and clinical presentation of Basal-cell carcinoma (BCC) vary among different ethnic subgroups. In the Hispanic population of Puerto Rico, the contribution of genetic ancestral factors in determining BCC risk and its clinical presentation is unknown. Methods: The study population consists of 83 BCC skin cancer cases and 89 controls recruited from a private dermatology practice in Ponce, Puerto Rico. A panel of 106 ancestry informative markers was genotyped using iPLEX Sequenom technology. Individual genetic ancestry was estimated using a maximum likelihood approach. The distribution of genetic ancestry was compared between cases and controls. Results: The distribution of genetic ancestry among the 172 study subjects varied from 0 to 89% African, 11 to 99% European, and 0 to 70% Native American. There was no significant difference in the average European (p= 0.891), African (p= 0.44) and Native American (p= 0.232) ancestry proportions between BCC cases and controls. Conclusions: Global genetic ancestry does not seem to contribute significantly to the risk of BCC in the Puerto Rican population. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 1681. doi:1538-7445.AM2012-1681