Abstract 16796: Persistent Anemia Associates Long-Term Higher Mortality in Patients After Percutaneous Coronary Intervention

Abstract

Introduction: Anemia is known to be associated with mortality in patients after percutaneous coronary intervention (PCI). However, the impact of temporal change in anemia on prognosis is not fully elucidated. Methods: We prospectively enrolled consecutive 4589 patients undergoing PCI from January 2000 to December 2016. Among them, patients, whose hemoglobin (Hb) level at PCI procedure (baseline) and follow-up coronary angiography (CAG, 6-12 months after PCI), were subjected to the study (n=1832). Patients were divided into 4 groups based on baseline and follow-up Hb level, such as anemia (-) to (-) (n=1122), anemia (-) to (+) (n=171), anemia (+) to (-) (n=159) and anemia (+) to (+) (n=380). Median follow-up period was 5.8±3.7 years. Results: Kaplan-Meier analysis showed that patients with persistent anemia, who had anemia at both baseline PCI and follow-up coronary angiogram (anemia (+) to (+)), had highest mortality rate, while survival rate in patients with recovered anemia (anemia (+) to (-)) was similar in patients without baseline anemia (anemia (-) to (-)) (p=0.01, anemia (+) to (+) vs. anemia (+) to (-)) (Figure). Adjusted Cox proportional hazard analysis showed that persistent anemia was an independent risk for all-cause mortality (Hazard-Ratio: 1.81, 95% confidential interval: 1.35-2.47, p=0.001). Conclusions: Persistent anemia, continuous anemia at PCI and 6-12 months later, is strongly associated with higher all-cause mortality.