Abstract
Abstract Nasopharyngeal carcinoma (NPC) is a multifactorial malignancy closely associated with genetic factors and Epstein-Barr virus (EBV) infection. To identify the common genetic variants linked to NPC susceptibility, we have conducted a genome-wide association study (GWAS) within the Taiwanese population, analyzing 480,365 single-nucleotide polymorphisms (SNPs). In this study, only 12 SNPs that can pass the statistical criteria for GWAS were reported and all of them located within chromosome 6 MHC region. However, those 12 SNPs can only explain a small fraction of genetic risk. The vase majority of the genetic risks remain undiscovered. Additional analytical procedures are vary likely to provide valuable information for NPC susceptibility. By utilizing 1000 genome data, we successfully expend SNP number to 37,512,779 SNPs. After removed SNPs with low quality (info <0.5) and no heterozygosity, we discovered additional 57,212 SNPs from whole genome imputation including 3,751 SNPs with P values <0.05. SNPs located in chromosome 1, 2, 3, 8, 15, 17 were selected for further validation. This work taking advantage of current genome sequencing database and significantly expand the range of associated SNPs that can also increase the chance to discover true association signals. Following functional investigation and experimental application of these findings are expected to produce new advances in the prevention and treatment of NPC. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 1669. doi:1538-7445.AM2012-1669
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