Abstract 16553: Association Between Family History and Isolated Early-Onset Atrial Flutter Across Race-Ethnicity

Abstract

Introduction: There is a genetic predisposition to early-onset atrial fibrillation (EOAF) but the role of family history in the pathogenesis of isolated EO atrial flutter (AFL) across racial and ethnic minorities remains unclear. Here, we determined whether probands with isolated EOAFL across race and ethnicity have a higher rate of AF in first-degree family members than matched control patients with late-onset (LO) AFL. Methods: In this cohort study, patients prospectively enrolled in a clinical and genetic biorepository were administered baseline questionnaires that included questions about family history of AFL. EOAFL was defined as AFL occurring in probands aged 60 years or younger in the absence of structural heart disease. All other forms were categorized as LOAFL. The main outcome measure was the reported family history of AFL in first-degree relatives. Results: Of 106 patients enrolled, 23 (23%) were European American; 53 (52%) were African American, 22 (22%) were Hispanic/Latino (H/L) and 3 (3%) were Asian American. There was a family history of AFL in 11 probands with EOAFL (18%) compared with 3 (7%) patients with LOAFL (Table 1). There was a significantly greater prevalence of CHF in the EOAFL group (40%) than the LOAFL group (21%). Conclusion: Probands with isolated EOAFL are more likely to have a first-degree relative with AFL when compared to matched controls with isolated LOAFL. Our findings support genetic predisposition to isolated EOAFL across racial and ethnic minorities.