Abstract 16114: Heart Failure Hospitalizations and In-Hospital Outcomes Among Patients With Schizophrenia - Nationwide Study

Abstract

Introduction: There is limited data regarding hospital outcomes in patients admitted with heart failure (HF) exacerbation and schizophrenia. Hypothesis: We sought to determine the characteristics and in-hospital outcomes of patients with schizophrenia admitted due to HF exacerbation in the United States. Methods: We performed a retrospective cohort study using the National Inpatient Sample database from January to December 2019. Patients with HF exacerbation (defined by ICD-10 codes) were categorized into two groups: patients with versus without schizophrenia and associated psychoses (defined by ICD-10 codes). Baseline variables and in-hospital outcome trends were compared between the 2 groups. Using logistic regression, we assessed the odds of use of invasive ventricular support device, and of in-hospital mortality. Results: In total, 9,780 hospitalizations for HF in patients with schizophrenia were identified, equivalent to 0.76% of all HF hospitalizations (n = 1,295,395). Patients with schizophrenia were younger (mean age 60 vs 71 years, p<0.05), more likely to be men (57% vs 52%, p<0.05), and more likely to have chronic pulmonary disease, obesity or be currently smoking. Comparing to overall HF patients, those with schizophrenia were more likely to be African American and live in zip codes at the lowest quartile of national income. After adjusting for patient-level, hospital-level demographics, and coexisting clinical conditions in a multivariable logistic regression there was no significant difference in the odds of in-hospital mortality between the two groups (OR 0.99, 95% CI, 0.63-1.60; P=0.99). No discrepancies in access to invasive ventricular support device were found (OR 0.42, 95% CI, 0.15 - 1.06, P=0.07). Conclusions: Patients with HF exacerbation and schizophrenia are more than one decade younger than overall HF population. Our study did not find difference in the odds of in-hospital mortality in patients admitted with HF exacerbation and schizophrenia in the United States.