Abstract 16081: Cardiovascular Outcomes of Individuals With Sleep Deprivation; a Retrospective Population-Based Analysis

Abstract

Introduction: Inadequate sleep quality and duration have been linked to adverse cardiovascular effects. Examining the cardiovascular outcome profile of the inpatient population with sleep deprivation (SD) has been relatively scarce. We aimed to study the outcomes in this setting. Hypothesis: We hypothesize that SD is associated with adverse cardiovascular outcomes, and studying the effect will help inform clinical care and prevention strategies. Methods: We used the ICD-10 code to identify all hospitalizations aged 18-85 with a primary or secondary SD diagnosis from the Nationwide Inpatient Database (NIS) 2016-2020. We excluded individuals with sleep apnea and those with established SD due to medical or psychiatric illnesses. A multivariate logistic regression model was used to account for confounders (including demography, smoking history, hospital setting, and insurance type) and estimate the probability of outcomes. Our outcomes of interest were hypertension (HTN), dyslipidemia (DysL), and obesity. Results: There were 27,294,891 hospitalizations aged 18-85 during the study period, and 2.6% (718,083) had a sleep deprivation diagnosis, mean age of 57.7 years ± 17. Of these, 74.8% (519497) were Caucasians, 12.1% (84463) were Blacks, and 8.1% (56316) were Hispanics. Individuals with SD had a higher likelihood of HTN, adjusted odds ratio (aOR) =1.28 (1.27-1.30, p<0.0001), DysL 1.3 (1.2-1.3, p<0.0001), and obesity 1.02 (1.01-1.02, p<0.0001). Conclusions: Our analysis showed that sleep deprivation was associated with a higher likelihood of hypertension, dyslipidemia, and obesity. Encouraging lifestyle modification, including adequate sleep hygiene, cannot be overstated.