Abstract 160: Interval From Collapse to Reaching Target Temperature Had No Impact for the Neurological Outcome in Post Cardiac Arrest Victims, Retrospective Cohort Study of J-Pulse-Hypo Registry

Abstract

Introduction: Currently, the ICEREA study, randomized controlled study of comparison between intravascular and surface cooling for post cardiac arrest syndrome (PCAS), did not show significant advantage of intravascular cooling to improve neurological outcome (Odds ratio 1.41, P = 0.07) (Circulation 2015;132:182-93). However, the study showed that intravascular cooling group showed significant shorter interval to reach 34 0 C (5.5 hr v.s. 8.5 hr, P<0.001). These results indicated the possibility of shorter cooling interval could improve neurological outcome of PCAS cases. Hypothesis: Shorter cooling interval could improve neurological outcome in PCAS cases. Methods: Inclusion criteria was witnessed, 34 0 C of target temperature (TT), and within 12 hr interval from collapse to reach TT. Three hundred were selected as eligible cases for this study from participants with J-PULSE-Hypo study database. The 300 cases were divided into 4 groups (A: interval from collapse to reach TT within 180 min, B: 181-360 min, C: 363-540 min, D: 541-720 min), and compared the favorable neurological outcome (CPC 1-2) by univariate and multivariate analysis. Results: Groups were A: 88 cases, B: 114 cases, C: 74 cases, and D: 24 cases. 477 participants were analyzed. The comparison of each groups for favorable neurological outcome, were not significant difference (A: 46%, B: 62%, C: 61%, and D: 63%, univariate: P = 0.109, multivariate: P = 0.812). Conclusions: Shorter cooling interval could not show advantage to improve neurological outcome in PCAS cases.