Abstract
Introduction: Optimal medical treatment demonstrated a reduction in cardiovascular outcomes after acute coronary syndrome. Treatment adherence results crucial to obtain that benefit, we do not have current data on the adherence in our population. Our objective was to evaluate the treatment adherence at 6 and 15 months in patients post non-ST elevation acute coronary syndrome (NST-ACS). Methods: It’s a prespecified sub-analysis in the prospective registry BUENOS AIRES 1 that include 1100 patients. The adherence was evaluated using the modified Morisky-Green scale. Results: The mean age was 65 ±11 years. At 6 month 76.4% were consider as adherents to pharmacological treatment. We didn’t find any predictors for adherence. Adherent patients had a rate of combined isquemic events (myocardial infarction, death or stroke) of 11.5% (52/452) versus 20% (27/135) in non-adherent patients at 15 months. Treatment adherence was an independent predictor of combined isquemic events (HR 0.517, IC95% 0.308-0.869, p=0.013). There weren’t any differences in the hemorrhagic events between the two groups. Conclusions: Our population had a high adherence treatment without any clinical predictor of this phenomenon. Adherence was related to a reduction in isquemic events without changing the hemorrhagic events. Nonetheless, one of four patients was considered as non-adherent after a hospitalization for NST-ACS, showing that we need intervention to reduce this number.
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