Abstract 1540: Inhibition of SDF production by brain tumor cells reduces brain tumor bed effect

Abstract

Abstract Previous study on a murine prostate tumor model, TRAMP-C1, has shown that tumor transplants in preirradiated (pre-IR) tissues have longer growth delay and lower microvascular density (MVD) than in nonirradiated tissues, a phenomenon known as the tumor bed effect (TBE) that is associated with less responsive to salvage radiotherapy or chemotherapy and higher risk of metastasis. This study further demonstrates that a murine astrocytoma, ALTS1C1, grown from pre-IR brain tissues also have obvious TBE. This indicates that there is also a brain TBE that may affect the therapeutic efficacy of recurrent brain tumor after radiotherapy. Additional study shows that the inhibition of SDF expression in ALTS1C1 by specific siRNA reduces pre-IR-induced tumor growth delay and TAM association with hypoxia. The vessel formation mechanism is also altered into more mature form. This indicates that SDF production by brain tumor cells plays significant roles on the response of recurrent brain tumors after radiotherapy to salvage therapy. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 1540. doi:1538-7445.AM2012-1540