Abstract 15300: Epidemiology and Risk of Anxiety and Depression Among Patients With Lown-Ganong-Levine Syndrome

Abstract

Introduction: Lown-Ganong-Levine (LGL) syndrome is a rare congenital pre-excitation syndrome with a perinodal accessory pathway. Arrhythmic events may lead to, or be influenced by, a myriad of psychological conditions such as anxiety and depressive disorders. There is no epidemiological data on the co-occurrence of these conditions in patients with LGL syndrome. We sought to describe the epidemiology and risk association of anxiety and depression in LGL syndrome. Methods: A multi-institutional database (Explorys Inc, Cleveland, OH, USA), with an aggregate of electronic health record data from 26 major integrated US healthcare systems, was surveyed. A cohort of patients with a Systematized Nomenclature of Medicine—Clinical Terms (SNOMED-CT) diagnosis of “Lown-Ganong-Levine syndrome” between 1999 and 2020 was identified. Demographic characteristics along with relevant clinical and social information were obtained. Results: Of 73,044,190 individuals in the database (1999-2020), 1,180 were given the diagnosis of LGL. Compared to subjects without LGL, patients with LGL syndrome were more likely to have anxiety (OR=5.9, p<0.001) and depression (OR=5.2, p<0.001). Within the anxiety and depression cohorts, LGL patients were more likely to be females, and had a higher association with smoking, alcohol and substance abuse. Anxiety but not depression was more common in young adults (18-65 years old). No difference in supraventricular arrhythmias was found between LGL patients carrying these psychiatric diagnoses with those who don’t. Conclusion: This is the largest study to date demonstrating the significant association between LGL and common psychiatric conditions. Care should be taken in identifying and managing such conditions as they, along with their pharmacologic therapies, may mimic or exacerbate the symptoms of LGL syndrome.