Abstract 15209: Effects of Coffee Consumption on Exercise Tolerance, Blood Pressure, Heart Rate, Heart Rate Variability and Premature Beats in Volunteers with Coronary Artery Disease

Abstract

Introduction: Coffee is supposed to increase blood pressure (BP) and heart rate (HR), which may be deleterious for patients with coronary artery disease (CAD). However a review of the literature reveals few studies evaluating these effects in patients with CAD. Objective: The aim of this study was to compare the effects of dark roast (DR) and medium dark roast (MDR) paper-filtered coffee on BP, exercise tolerance, HR, heart rate variability (HRV) and extrasystoles in volunteers with CAD. Methods: This randomized crossed-over trial compared the effects of consuming three or four cups (150 mL) of DR and MDR coffee per day for 4 weeks in 40 volunteers with CAD. In the baseline and after each 4 weeks period of drinking they were submitted to treadmill test, ambulatory blood pressure monitoring (24-h ABPM) and 24-h Holter ECG. We analyzed average systolic BP (SBP) and diastolic BP (DBP) at 24-h ABPM, total exercise time ([[Unable to Display Character: ∆]]T Exercise) and double product (DP) at treadmill test, and average HR, SDNN, ventricular (VPB) and supraventricular premature beats (SPB) at 24-h Holter ECG. Variables were evaluated by ANOVA for repeated measures and Friedman test when indicated. Results: We evaluated 40 subjects with CAD, 64.7 ± 6.7 years old, 32 men. All volunteers received adequate treatment for CAD according to the guidelines. Compared with baseline, subjects had an increase of 6.4% and 5.7% in [[Unable to Display Character: ∆]]T exercise at treadmill test after MDR and DR consumption respectively [565.8 ± 194.8 vs 601.8 ± 212.9 vs 597.8 ± 208.0 s (p=0.001)] without an increase in DP (p=0.91). In the 24-h Holter ECG at baseline, DR and MDR the following values were obtained, respectively: HR [67.1 ± 8.6 vs 66.5 ± 8.2 vs 67.2 ± 8.5 (p=0.71)], SDNN [130.6 ± 32.7 vs 134.2 ± 30.6 vs 129.7 ± 28.5 (p=0.428)], VPB [8.0 (2.0-395.5) vs 9.5 (0.2-54.7) vs 11.5 (3.0-51.7) (p=0.16)] and SPB [18.0 (5.2-73.0) vs 20.0 (5.5-75.5) vs 16.5 (6.2-72.5) (p=0.52)]. In the 24-h ABPM at baseline, DR and MDR the following values were obtained, respectively: SBP [110.8 ± 9.1 vs 109.2 ± 19.9 vs 114.7 ± 11.8 mmHg (p=0.10)] and DBP [64.1 ± 9.1 vs 64.6 ± 9.3 vs 66.4 ± 9.7 mmHg (p=0.14)]. Conclusions: Paper-filtered coffee increased exercise tolerance and had no considerable effect on BP, HR, HRV and premature beats in volunteers with CAD.