Abstract 149: Postpartum Cognitive Function in Young Women With a History of Preeclampsia: Association With Blood Pressure but Not Large Artery Stiffness

Abstract

Introduction: Women with a history of preeclampsia (PE) have elevated large artery stiffness and blood pressure (BP) several years postpartum. Age-related increases in aortic stiffness are deleterious to brain structure and cognitive function; however, the relationship between large artery stiffness and cognitive function has not been assessed in women with a history of PE. The purpose of this study was to determine the extent to which large artery stiffness and BP are associated with cognitive function in women with a history of PE. Methods: Women with a history of PE (n=12; age 33±1 yrs; BMI 28.5±3.1 kg/m 2 ) and healthy pregnancy controls (n=7; age 34±2 yrs; BMI 26.5±4.0 kg/m 2 ) were assessed one year postpartum. Brachial BP was collected in triplicate using an automated cuff. Aortic stiffness was measured via applanation tonometry and quantified as carotid-femoral pulse wave velocity (cfPWV). Carotid stiffness (β-stiffness) was obtained via ultrasonography and carotid tonometry. Cognitive function was assessed in domains of memory, processing speed, and executive function. Results: Women with a history of PE had higher systolic BP (121±4 vs. 104±3 mmHg, p<0.01) and cfPWV (6.2±0.4 vs. 5.1±0.2 m/s, p=0.06), though the latter did not reach statistical significance. There was no difference between groups in β-stiffness (6.1±0.4 vs. 6.1±0.6 U, p=0.97). Cognitive domains of executive function, memory, and processing speed did not differ between groups (all p>0.05). Systolic BP was associated with reductions in executive function (r = -0.52, p=0.04) independent of education level, but was not related to reductions in memory or processing speed. Arterial stiffness was not associated with cognition. Conclusions: Women with a history of PE had elevated systolic BP and aortic stiffness, but only BP was associated with reductions in executive function. These preliminary findings suggest that young women with a history of PE may be vulnerable to reductions in cognitive function related to persistent elevated systolic BP.