Abstract 1487: Rotating 3D projections of prostate lesions imaged by Cu-64-VPAC1 ligand PET and CT

Abstract

Abstract Surgeons are obliged to examine multiple planar images of fine needle biopsies, CT, and PET images for diagnosis and evaluation of prostate cancer. We hypothesize that optimal comprehension of prostate lesions in the prostate, as they present in the surrounding tissue, will be achieved by 3D registration and presentation of all available images. In particular, PET imaging of a cancer cell surface marker maximizes specificity, relative to imaging of F-18-deoxyglucose uptake. We have demonstrated specific PET imaging in patients of vasoactive intestinal peptide and pituitary adenylate cyclase activating peptide receptor 1 (VPAC1), which is overexpressed on breast cancer and prostate cancer cells. Our PET agent is Cu-64-TP3805, a peptide derived from vasoactive intestinal peptide. From our ongoing prostate cancer patient imaging study, we segmented and co-registered CT image slices and TP3805 PET image slices, then created moving 3D images. Viewing the rotating 3D images from all sides revealed clear delineation of prostate lesions from the adjoining bladder. The lesion images colocalized in space with intraprostatic tumor foci identified from H&E staining of whole mount slices after prostatectomy. Thus, rapid 3D presentation of anatomical, histological, and molecular images could be a useful preparative tool to minimize complications during prostate cancer surgery. This result supports proceeding to 3D analysis of a larger prostate cancer cohort. Citation Format: Matthew E. Wampole, Bishnuhari Paudyal, Edouard J. Trabulsi, Mathew L. Thakur, Eric Wickstrom. Rotating 3D projections of prostate lesions imaged by Cu-64-VPAC1 ligand PET and CT. [abstract]. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; 2015 Apr 18-22; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2015;75(15 Suppl):Abstract nr 1487. doi:10.1158/1538-7445.AM2015-1487