Abstract
Background: To date, there is no study regarding the impact of chronic atrial fibrillation (AF) on clinical outcomes following percutaneous transluminal angioplasty (PTA) in patients (pts) with symptomatic peripheral arterial disease (PAD). Methods: We investigated the 512 consecutive symptomatic PAD pts underwent PTA from September 2004 to December 2013. Individual and composite cumulative clinical outcomes of PAD pts with AF (n=465) at 1 year were compared with those of PAD pts with normal sinus rhythm (NSR, n=47). Results: In baseline characteristics, there were no significant differences in baseline clinical characteristics including gender, smoking, hypertension, diabetes, dyslipidemia, cerebrovascular accident (CVA), chronic renal insufficiency, dialysis, coronary artery disease, myocardial infarction, symptoms of PAD such as claudication, resting pain, wound, and gangrene between the two groups except age; The AF group tended to be elder than non-AF group (67.15±10.56 years vs. 70.21±8.93 years, respectively, p=0.051). At 1 year, there was no significant differences in major clinical outcomes such as the incidence of repeat PTA, target lesion revascularization (TLR), target extremity revascularization (TER), target extremity surgery (TES), above-the-knee amputation, above-the-ankle amputation, below-the-ankle amputation, acute myocardial infarction (AMI), percutaneous coronary intervention (PCI), and major adverse cerebrocardiovascular events (MACCEs) between the two groups. However, after adjustment of baseline confounders, the incidence of total death, cardiac death, and CVA were higher in the AF group as compared with non-AF group (Table). Conclusions: In our study, symptomatic PAD pts underwent PTA combined with AF was associated with higher incidence of mortality and stroke up to 1-year as compared with PAD pts with NSR.
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