Abstract 14809: Longitudinal Trends in the Incidence of Covid-19 in Acute Myocardial Infarction Patients

Abstract

Introduction: Existing studies have reported association between acute myocardial infarction (AMI) and risk of fatal outcomes in COVID-19 patients. However, impact of Omicron COVID-19 variant on the incidence of AMI has not been studied. We aimed to ascertain longitudinal trends in incidence of COVID-19 in AMI patients with a focus on the Omicron period. Methods: We included all hospitalized patients from March 2020 to January 31 st , 2022 at all Cleveland Clinic hospitals in the U.S. who had an ICD-10 code I21 representing AMI. Data was obtained using Slicer Dicer. Primary outcome was longitudinal trends in incidence of COVID-19 in AMI patients and secondary outcome was the incidence of COVID-19 in Omicron as compared with previous waves. Hospitalisations were stratified based on following periods: stay at home order [03/2020-05/2020]; pre-vaccination [06/2020-01/2021]; post-vaccination but before delta wave [02/2021-06/2021]; delta wave [07/2021-08/2021]; and Omicron wave [12/2021-01/2022]. Trends over study period were assessed using Mann-Kendall test. Comparison of outcomes across different COVID-19 pandemic periods was performed using the chi-square test. Results: Total of 14908 hospitalizations were identified. Overall incidence rate of COVID-19 in AMI patients was 7.62% (1137/14908). From March 2020 until January 31 st , 2022, there has been a significant increase in incidence rate of COVID-19 in AMI patients from 0.83% to 29.92%, p=0.006. Incidence rate of COVID-19 in AMI during the Omicron period (25.7% (322/1252)) was significantly higher compared with the stay at home order (2.3%), pre-vaccination (8.2%), post-vaccination (4.3%), and delta wave (3.7%), p<0.001. Furthermore, incidence of COVID-19 in AMI patients decreased post-vaccination period until emergence of Omicron variant. Conclusions: There has been a significant increase in the incidence of COVID-19 amongst the AMI patients which is attributed to the emergence of Omicron variant.