Abstract 14427: Subclinical Age- and Sex-Differences in Ventricular Strain in the Community: A Framingham Heart Study Cardiac Magnetic Resonance Study

Abstract

Introduction: Myocardial strain is a measure of deformation and a marker of cardiovascular disease (CVD). The subclinical age- and sex-associations of left and right ventricular (LV, RV) strain by feature tracking cardiovascular magnetic resonance (FT-CMR) are not well established in the community. Methods: Framingham Heart Study Offspring cohort participants (n=1077) without prevalent CVD, hypertension, diabetes, or use of treatment for these conditions underwent 1.5T CMR. Steady-state free precession cine images spanning the entirety of both ventricles were acquired in the short-axis, 2-chamber, and 4-chamber views. Global longitudinal (GLS), circumferential (GCS), and radial (GRS) strains were measured by FT-CMR (Circle cvi42 v.5.11.1). Comparisons among age groups (<45 years, 45-54 years, 55-65 years, and >65 years) were performed by one-way analysis of variance and between sexes by independent samples t -test. Results: Clinical characteristics, CMR measures, and LV and RV strain by age and sex for the cohort are presented in the Table . Across increasing age groups, we observed more favorable LV GLS, GCS, and GRS (p=0.010, p<0.001, and p<0.001, respectively). Similar trends were present for RV strain for GCS and GRS (both p<0.001) but not GLS (p=0.22). Compared with men, women had greater magnitude (more favorable) LV and RV strain values for GLS, GCS, and GRS (all p≤0.013). Conclusions: In this large community based study of individuals without CVD, LV and RV strains by FT-CMR were greater (more favorable) with increasing age and in women. The associations and long-term implications of these differences in myocardial mechanics between groups require further investigation.