Abstract
Abstract Global DNA hypomethylation may result in chromosomal instability and cancer risk. This study was performed to determine the association between DNA hypomethylation in derived from whole blood and non-Hodgkin lymphoma. We analyzed DNA of 506 NHL and 1680 control subjects at Chonnam National University Hwasun Hospital, Korea. Global DNA methylation levels were assessed using bisulfited-PCR pyrosequencing of long interspersed nuclear element-1 (LINE-1). All participants were subsequently categorized into quartiles by mean % in control. When the highest quartile was considered as a reference category (Q4), the following adjusted odds ratios (OR) and 95% confidence intervals (95% CI) were observed for decreasing methylation quartiles OR(Q3)=2.36 (95% CI:1.40-3.97); OR(Q2)=4.67 (95% CI: 2.89-7.55) and OR(Q1)=17.56 (11.19-27.56). This is, to the best of our knowledge, the first study to show that global DNA hypomethylation was significantly associated with increased for NHL risk in a large case-control study. These findings suggest that global methylation levels in genomic DNA may be play important role in the NHL risk. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 143.
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