Abstract #1409761: Weight Change in Patients with New-Onset Type 2 Diabetes and its Association with Spontaneous Remission – A Comprehensive Real-World Data

Abstract

This is a population-based cohort study aimed to understand on weight change in new-onset type 2 diabetes patients receiving standard medical therapy and how much weight loss contributes to diabetes remission. From the Korean National Health Insurance Service, type 2 diabetes patients who were newly prescribed diabetes medication two or more times within one year were screened. Remission was defined as cases where the fasting glucose was less than 126 mg/dL at two or more consecutive health examinations after stopping medication. A total of 114,874 new-onset type 2 diabetes patients was analyzed. Of these, 23,156 (20.2%) lost more than 5% of their body weight, and 2,429 (2.1%) acheived remission. The adjusted odds ratio for reaching remission of weight loss group was 2.56 (95% confidence interval 2.35-2.79) compared to the group with stable body weight. The effects of weight loss on remission were significantly greater in subgroups of age younger than 65 years, male sex, and body mass index greater than 25. Losing more than 5% of body weight may increase the likelihood of diabetes remission. We suggest that physicians pay more attention to weight management in new-onset type 2 diabetes, especially for young and obese patients.