Abstract 14081: Higher Fish Intake and a Healthy Lifestyle May Be Associated With a Lower Platelet Count/Lymphocyte Count Ratio: Implication for the Anti-Atherosclerotic Effect of Fish Intake

Abstract

Introduction: Higher fish intake and healthy lifestyle behaviors are associated with a reduced risk of atherosclerotic cardiovascular disease (ASCVD). A higher platelet count/lymphocyte count ratio (PLR), an inflammatory predictive marker of ASCVD, is reportedly associated with a higher incidence of CVD. Hypothesis: We hypothesized that higher fish intake would be associated with lower PRL, and a healthy lifestyle would also be associated with lower PLR. Methods: We conducted a cross-sectional study between April 2019 and March 2020 at the Health Planning Center of Nihon University Hospital in a cohort of 5957 participants (average age, 46.7 ± 12.9 years; 58.9%, men) with no history of ASCVD. We calculated the amount of fish intake based on the average number of days of fish intake per week and data from the Japanese National Health and Nutrition Survey. Results: The average weekly frequency and amount of fish intake were 2.25 ± 1.30 days and 140.5 ± 86.7 g, respectively. As the weekly fish intake increased (< 50, 50-100, 100-150, 150-200, 200-250, 250-300, and ≥ 300 g), the PLR significantly decreased (p < 0.0001). A multivariable logistic regression analysis identified higher fish intake as an independent determinant of a lower PLR. Aerobic exercise was also an independent negative determinant of PLR. Furthermore, with increasing frequency of fish intake, the proportion of participants engaging in habitual aerobic exercise increased (p < 0.0001). Conclusions: The results suggest that a higher fish intake and a healthier lifestyle related to fish intake habits are associated with a lower PLR and thus may exert beneficial anti-inflammatory effects. This association may explain the preventive effects of fish intake on ASCVD risk. Further investigations are needed to clarify the causal relationships between these factors.