Abstract 14079: Association Between Serum Uric Acid Level and Metabolic Syndrome in a Rural Japanese Population: A Multi-Center Study

Abstract

Introduction: Several reports have showed associations between serum uric acid (UA) levels and metabolic syndrome (MetS). Limited information, however, is available concerning the prospective relation between UA and the risk of developing MetS. Hypothesis: Hyperuricemia would be related to higher odds for MetS in a rural Japanese population. Methods: We evaluated 2406 subjects (1275 male subjects, 1131 female subjects; mean age 49.9 years) who underwent health examination programs in 2008 and 2013, who were free of MetS in 2008. We conducted this multi-center study in two hospitals located in northern Hiroshima prefecture. Results: At baseline, hyperuricemia was detected in 258 male subjects (20%) and 41 female subjects (3.6%). Subjects with hyperuricemia at baseline had significantly higher MetS prevalence in 2013 than those without (male subjects: 14.7% vs. 9.1%, P=0.01; female subjects: 9.8% vs. 1.7%, P=0.008). Compared with subjects in the first quartile of uric acid levels at baseline, the age-adjusted odds ratios (ORs) for cumulative incidence of MetS among subjects in the second, third, and fourth quartile were, 0.77 (95% confidence interval (CI), 0.40-1.48; P=0.43), 1.79 (95% CI, 1.05-3.06; P=0.03) and 2.17 (95% CI, 1.28-3.70; P=0.004), for male subjects. Compared with subjects in the second quartile of uric acid levels at baseline, the age-adjusted ORs for cumulative incidence of MetS among subjects in the third, and fourth quartile were 2.46 (95% CI, 0.47-12.9; P=0.29), 7.34 (95% CI, 1.65-32.6; P=0.009), for female subjects. Multivariable logistic analysis revealed that hyperuricemia was significantly associated with cumulative incidence of MetS in male and more significantly in female subjects (male: OR, 1.79 [95% CI, 1.19-2.69; P=0.005], female: OR, 6.34 [95% CI, 2.03-20.0; P=0.002]). Conclusions: Hyperuricemia is a significant predictor of MetS in rural Japanese population and more significantly in female.