Abstract 14030: Hemodynamic Metrics Can Be Accurately Assessed by a Non-Invasive Sensor Patch: The Portable Technology for Wireless Cardiomyopathy Tracking (Patchwrk) Study

Abstract

Background: Echocardiographic timing intervals provide valuable prognostic information in patients with pre-clinical cardiac dysfunction. Diastolic filling time (DFT) can identify left bundle branch block (LBBB) patients at higher risk for cardiomyopathy. The need for specialized equipment limits the utility of echo in longitudinal assessment. Hypothesis: A non-invasive multimodal sensor Sansa patch will enable accurate assessment of hemodynamic parameters such as DFT, ejection time (ET), and pre-ejection period (PEP). Methods: Fifty patients scheduled for clinically indicated echocardiography were prospectively enrolled and had simultaneous application of the Sansa patch at the time of echocardiography. Timing intervals were analyzed using continuous wave (CW), pulsed wave (PW), and tissue Doppler imaging (TDI). Data from the Sansa electrocardiogram (ECG), seismocardiogram (SCG), and phonocardiogram (PCG) were independently analyzed to identify valve openings/closures to estimate DFT, ET and PEP. Agreement between echo and Sansa estimates was assessed using the coefficient of determination (R 2 ) and compared with agreement between different echo views. Results: Forty-six of the 50 patients (92%) had data of sufficient quality for analysis. The mean ejection fraction was 53±8% and 11 patients (24%) had LBBB. By echo, the mean DFT, ET, and PEP were 408±137 milliseconds (ms), 297±35ms, and 107±32ms respectively. Sansa estimates for DFT, ET and PEP were 431±135ms, 286±43ms, and 89±34ms respectively. The R 2 for Sansa DFT compared to echo was 0.85. Comparing TDI and PW estimates of DFT within the same patients demonstrated an R 2 of 0.82. Conclusion: Non-invasive Sansa patch monitoring accurately identified key cardiac timing intervals within the error observed between standard echo views. These measures have prognostic value and monitoring them in the ambulatory setting may allow early cardiomyopathy detection and upstream intervention.