Abstract 13840: Trends in Incidence and Long-Term Prognosis of Acute Kidney Disease Following Coronary Angiography in Chinese Cohort With 9,665 Patients From 2008 to 2017: An Observational Study

Abstract

Introduction: Acute Kidney Disease (AKD) is a disease that recently received close attention and was found prone to a poor prognosis. However, few studies have explored the trends of the incidence and prognosis of AKD over the last decade. Methods: This retrospective cohort study collected data from 9,665 patients who underwent CAG. Their preoperative and postoperative serum creatinine (Scr) values within 7-90 day were analyzed for the period of January 2008 to December 2017. Univariate and multivariate logistic regression analyses were used to estimate the odds ratio of AKD between 2008 and 2017. Survival data were evaluated using univariate and multivariate Cox regression analyses. Results: The research team analyzed a total of 9,665 patients in Guangdong Provincial People’s hospital, with an average age of 61.6±9.6 years and 40.1% (3,876) females. The overall incidence of AKD in that decade was 18.8%, and the overall mortality rate was 323.0 per 1,000 person-years. Compared with 2008, the incidence of AKD in 2017 decreased from 25.1% to 12.8% (Adjusted odds ratios [a OR], 0.40, 95%CI, 0.31-0.51, P-value <0.01, P for trend <0.01). On the contrary, 323.0‰ AKD patients died in total, significantly increased from 138.2 to 544.1 per 1,000 person-years in 2008 (Adjusted hazard ratio [a HR], 2.85; 95%CI, 1.20-6.73; P-value =0.02, P for trend=0.02). These findings were consistent across different gender and age groups. Conclusions: From 2008 to 2017, the incidence of AKD decreased significantly, while AKD associated mortality showed a notably increased trend. Our findings support more active measures to prevent AKD and improve the prognosis of AKD patients