Abstract 13830: Impact of Atrial Fibrillation on Clinical Outcome of Femoropopliteal Artery Intervention in Critical Limb Ischemia

Abstract

Introduction: Clinical outcome of patients with atrial fibrillation (AF) after endovascular therapy for critical limb ischemia (CLI) is unclear. The aim of this study was to investigate if atrial fibrillation (AF) influences clinical outcomes after femoropopliteal artery intervention in patients with CLI. Methods: A retrospective review of all patients undergoing femoropopliteal artery intervention for CLI was performed. We compared clinical outcome between patients with and without AF. The primary endpoint was amputation free survival (AFS). The secondary endpoints were overall survival, limb salvage, freedom from repeat revascularization, and freedom from surgical conversion were compared between two groups. Kaplan-Meier analyses were performed to assess time-dependent outcomes. Factor analyses were performed using a Cox proportional hazard model for time-dependent variables. Results: A total of 398 limbs with 342 patients were performed with femoropopliteal artery intervention in patients with CLI. (male 58.4%, 73.9±10.8 years old, mean follow up 17 months; interquartile range 5-32 months). We identified 58 limbs with AF, 340 without AF. At median follow-up period, AFS and overall survival was significantly lower in patients with AF (51.0 % vs 70.5 % P=0.0004 by log-rank, 53.9 % vs 77.1 % P<0.0001; relatively). Other outcomes were not significantly different between the groups. Risk-adjusted Cox proportional hazards regression showed that AF predicts poor AFS and overall survival (hazard ratio [HR], 1.59; 95% confidential interval [CI] 1.01-2.43; adjusted P=0.044, HR, 1.89; 95%CI, 1.19-2.98; adjusted P=0.008). Conclusion: AF may worse AFS and overall survival rate in patients who underwent femoropopliteal intervention in CLI.