Abstract 13793: The Impact of Right Ventricular Trabeculation in Patients With Left Ventricular Noncompaction

Abstract

Right ventricular (RV) involvement in left ventricular noncompaction (LVNC) remains unknown. We aimed to describe the RV volumetric, functional, and strain characteristics and clinical features of patients with LVNC and good LV ejection fraction (EF) using cardiac magnetic resonance, to identify differences between LVNC patients with (RV-HT) and without RV hypertrabeculation (RV-NT) and to describe the relationship between RV and LV trabeculation and RV volume and function. One hundred Caucasian patients with LVNC and good LV-EF and 100 age- and sex-matched healthy controls were included in this retrospective study. Patients were further divided into two subgroups by the amount of RV indexed trabecular mass (RV-TMi). We measured the LV and RV volumetric, functional and TMi values using threshold-based postprocessing software and the RV and LV strain values using feature tracking and collected the patients’ LVNC-related clinical features. Patients had higher RV volumes, lower RV-EF and worse RV strain values than controls. A total of 22% of patients had higher RV-TMi values than the previously described reference range; furthermore, RV-HT patients had higher RV and LV volumes, lower RV- and LV-EF and worse RV strain values than RV-NT patients. We identified a strong positive correlation between RV- and LV-TMi and between RV-TMi and RV volumes and a significant inverse relationship between both RV- and LV-TMi and RV function. The prevalence of LVNC-related clinical features was similar in the RV-HT and RV-NT groups. These results suggest that some LVNC patients might have RV noncompaction with subclinical RV dysfunction, raising further questions about its prognosis.