Abstract #1375340: Correlation of Follicle Stimulating Hormone and Luteinizing Hormone Levels with HbA1c in Post-Menopausal Females

Abstract

Menopause in female is a normal physiological process however, it is also a well-established risk factor for CVD and osteoporosis. Few studies suggest that low FSH is associated with adiposity and diabetes in post-menopausal women. Aim of this study was to explore correlations of follicle stimulating hormone (FSH) and luteinizing hormone (LH) levels with HbA1c level in post-menopausal females. The study was conducted at of Dr. S.N. Medical College, Jodhpur, India. Otherwise healthy postmenopausal women attending hospital for preventive health checkup were included in study. Postmenopausal status was confirmed by the absence of menses for at least 12 months. Known case of T2D/T1D, subjects on hormone replacement therapy, acutely sick were excluded from study. The baseline fasting blood samples were collected. Samples was assayed for FSH, LH, HbA1c and standard biochemical profile (glucose, lipid profile, Live function tests and renal function tests) using standard methods. The participants were classified as having diabetes or prediabetes using ADA criterias. Total 229 postmenopausal women were enrolled. Mean age of subjects was 63.2±9.9 years. Mean Hba1c was 6.2±1.4 gm% and subjects were further divided in to non-diabetes (68/229), prediabetes (104/229) and diabetes group (57/229) according to Hba1c levels. Mean LH was 25.8±15.6, FSH was 61.1±30.1 and LH/FSH ratio was 0.47±0.35. Mean LH was 31.4±15.8, 26.0±16.3, 19.5±12.6 in non-diabetes, prediabetes and diabetes group respectively. Mean FSH was 75.9±29.3, 59.6±27.6, 46.9±29.0 in non-diabetes, prediabetes and diabetes group respectively. The LH and FSH values in non-diabetes and diabetes group were statistically significant (p<0.01). In this study low FSH and LH levels were associated with higher level of HbA1c and increased risk of T2D.