Abstract 13748: Predictors of Yellow Neointima After Stent Implantation in the Superficial Femoral Artery

Abstract

Background: Neoatherosclerosis is known to occur after coronary stenting, but whether it occurs following stenting in the superficial femoral artery (SFA) remains unknown. Methods: This study comprised angioscopic evaluations of 149 stents implanted in the 102 SFA lesions from 92 patients from April 2012 to September 2014. Complete neointimal coverage (defined as struts fully embedded and invisible) was found in 87 stents in the 67 native lesions from the 61 patients. We compared characteristics between the cases with (23 stents, 26%) and without yellow neointima (YN) at the site of complete neointimal coverage, and evaluated the predictors of YN. Results: Median follow-up duration was significantly longer in the YN(+) than YN(-) group (370 [interquartile range: 282-884] days vs. 350 [95-394] days, P<0.001), while patient characteristics, medication use, rate of drug-eluting stent and bare-metal stent use (48% vs. 50%, P=1.0), and lesion and procedural characteristics were similar between them. Low-density lipoprotein cholesterol (LDL-C) level at intervention was higher in the YN(+) than YN(-) group (109±25 mg/dL vs. 97±25 mg/dL, P=0.049). At angioscopic follow-up, LDL and total cholesterol (TC) levels were higher in the YN(+) than YN(-) group (109±27 mg/dL vs. 97±25 mg/dL, P= 0.046; and 188±33 mg/dL vs. 172±34 mg/dL, P=0.048, respectively). Conclusions: YN was associated with the degree of dyslipidemia, suggesting the presence of neoatherosclerosis in the SFA following stenting.