Abstract 13525: Plateletcrit: A Novel Risk Predictor of Acute Myocardial Infarction

Abstract

Introduction: Platelets are crucial in the pathogenesis of acute coronary syndrome (ACS). Naïve platelets are larger in size and have higher thrombotic activity compared to smaller platelets. The plateletcrit (PCT), representing the total platelet mass, may emerge as a marker of prothrombotic state in ACS patient. Hypothesis: Increased PCT is associated with higher risk of acute MI in young patients (≤40 years). Aim: To find out PCT levels in young AMI patients. Methods: A hospital-based case-control study at Dhaka Medical College Hospital, Bangladesh were carried out. 50 young newly diagnosed AMI (both STEMI & NSTEMI) patients presented to CCU and 50 age- and sex-matched healthy controls were studied. Platelet indices i.e., PCT, Mean platelet volume (MPV) and platelet count were measured upon admission. The correlation between PCT, clinical and laboratory parameters were examined with Pearson Spearman analysis. Multivariate logistic regression was used to evaluate the role of PCT in predicting AMI. Receiver operating characteristic (ROC) curve analysis was done to obtain the optimal cut off for significant variables. 95.0% confidence interval and p <0.05 were considered statistically significant. Results: In AMI patients, the mean platelet count, mean PCT and mean MPV were 258 х 10 3 /μl, 0.30% and 11.09fl, respectively. In the control population, the mean platelet count, mean PCT and mean MPV were 245х10 3 /μl, 0.26% and 10.29 fl, respectively. PCT showed the most significant association with AMI with odds ratio 3.89, followed by an OR of 2.38 for MPV. PCT showed higher sensitivity and specificity (84.8% and 67.2%, respectively) in comparison to MPV (66% and 68%, respectively) ( p <0.001 vs 0.003). There was a significant positive correlation between PCT and serum troponin-I level. Conclusion: Patients with higher PCT was at higher risk of AMI and myocardial damage. This routine inexpensive and readily available PCT may be of value as a complementary marker in early AMI.