Abstract 13452: Clinical Usefulness of Oxygen Uptake Efficiency Slope for Evaluation Functional Capacity of Heart Failure With Preserved Ejection Fraction

Abstract

1. Backgrand: The diagnostic criteria for HFpEF have been established; however, the evaluation criteria for functional capacity, such as LVEF in HFrEF, have not been clearly delineated. Furthermore, exercise intolerance is a prominent manifestation in patients with HFpEF.Considering these factors, the objective of this study was to analyze the results of cardiopulmonary exercise testing (CPET) in the HFpEF patient cohort and utilize them for the assessment of functional capacity. 2. Methods: Exercise echocardiographic data were retrospectively analyzed in a cohort of 83 patients who underwent exercise echocardiography between September 2021 and October 2022. Among them, 64 patients also underwent cardiopulmonary exercise testing (CPET). The diagnostic criteria for HFpEF were determined based on the ASE/EACVI algorithm, as outlined below. 3. Result: Notably, only in the case of the oxygen uptake efficiency slope (OUES), the patient group with diastolic dysfunction displayed a statistically significant result that was significantly lower than that of the group with normal diastolic function. Based on these findings, when the ROC curve was generated using OUES as the negative predictive value, the AUC was 0.708, indicating a fair result. 4. Conclusions: The decrease in OUES was found to be statistically significant in HFpEF patients. As a result, it is anticipated that OUES can serve as a measure for evaluating functional capacity in HFpEF patients, in addition to serving as an objective indicator of improved cardiopulmonary exercise capacity when treating HFpEF patients.