Abstract 1344: Novel targeting all-in-one nanoporphyrin platform against bladder cancer

Abstract

Abstract We have developed an extremely versatile and highly innovative theranostic nanoporphyrin (NP) platform for the integration of a broad range of clinical relevant imaging and therapeutic functions, including magnetic resonance imaging (MRI), positron emission tomography, fluorescence optical tomography, photodynamic therapy, photothermal therapy and targeted drug delivery. NPs exhibit architecture-dependent fluorescence- and magnetic resonance- properties, which could significantly increase the sensitivity of optical imaging and MRI for tumor detection. We recently integrated the NP platform into our previously reported bladder cancer targeted nanoparticles that were coated with a bladder cancer-specific ligand named PLZ4, resulting in a novel bladder cancer targeting and multifunctional PLZ4-nanoporphyrin (PNP) platform. PNP selectively delivered photosensitizer and chemotherapy into bladder cancer cells 30-50 times more than to adjacent normal urothelial cells, compared to only 2-3 times with reported photosensitizer, 5-aminolevulinic acid (ALA). Photodynamic therapy with PNP generated reactive oxygen species was over 100 times more potent than 5-ALA in vitro. PNP-mediated intravesical photo-therapy completely eliminated orthotopic patient-derived bladder cancer xenografts (PDXs). Image-guided photodynamic and photothermal therapies synergized with targeted chemotherapy of doxorubicin and significantly prolonged overall survival of mice carrying PDXs. This uniquely engineered targeting PNP platform has tremendous potential to improve the management of bladder cancer in clinic. Citation Format: Yuanpei Li, Tzu-yin Lin, Chongxian Pan, Kit S. Lam. Novel targeting all-in-one nanoporphyrin platform against bladder cancer. [abstract]. In: Proceedings of the 107th Annual Meeting of the American Association for Cancer Research; 2016 Apr 16-20; New Orleans, LA. Philadelphia (PA): AACR; Cancer Res 2016;76(14 Suppl):Abstract nr 1344.