Abstract 13349: An Investigation Into the Association Between Inflammatory Bowel Disease and Cardiac Arrhythmias an Examination of the United States National Inpatient Sample Database

Abstract

Introduction: A growing evidence depicted the role of systemic inflammation in the pathogenesis of cardiac Arrhythmias (CA). However, uncertainty remains as to the exact relationship between Inflammatory Bowel Disease (IBD) and CA. So far, most of the studies had centered on the implication of inflammatory mechanisms in the development of atrial fibrillation (AF) in IBD. The association between IBD and other arrhythmias is not well elucidated. Hypothesis: We hypothesized that IBD might be associated with a higher burden of CA. Methods: We queried the national inpatient sample (NIS) from 2012 to 2014. Discharges associated with IBD (Chron's or ulcerative colitis), cardiac arrhythmias including AF, Atrial flutter, SVT, VT, VF were identified using ICD-9-CM codes 555.xx, 556.xx, 427.3, 427.32, 427.0, 427.1, 427.41, respectively. We divided patients into two groups, IBD Vs. Non-IBD. Outcomes are the prevalence of CA (AF, A.flutter, SVT, VT, V.fib) amongst both groups, as well as the correlation between CA and demographic of patient cohorts. Multivariable logistic regression (MLR) was utilized to adjust for differences in baseline characteristics. Results: We identified 847,235 weighted hospitalizations among patients with IBD and 84,757,349 hospitalizations among the general population, ≥18 years of age. Overall, IBD patients were less likely to be admitted with cardiac arrhythmias than the non-IBD population (9.7% versus 14.2%, P, <0.001). On MLR, IBD Group had lower odds of CA during hospitalization (OR, 0.87; 95% CI 0.85-0.88), AF (OR, 086; 95%CI 0.85-0.88) A.flutter (OR,0.78; 95% CI 0.74-0.83), VF (OR, 0.69; 95% CI 0.59-0.79). While the prevalence of SVT and VT was not different between the two groups. Male sex, age of more than 60 years, and white Race were risk factors for Arrhythmias. Conclusions: In conclusion NIS analysis revealed lower rates of hospitalization-associated arrhythmias in the IBD population compared to the general population.