Abstract 13288: Higher Non-High Density Lipoprotein Cholesterol is Associated With Arterial-Ventricular Stiffening in Childhood Obesity

Abstract

Background: Serum non-high density lipoprotein cholesterol (HDLC) is known to be a good predictor of cardiovascular events. However, few studies have examined non-HDLC and cardiovascular function in overweight/obese children. The purpose of this study is to assess the relationship between non-HDLC and cardiovascular function in children. Methods: Echocardiography was performed in 243 children aged 7 to 15 years (BMI 18 to 34 kg/m2). Left ventricular (LV) end-diastolic volume, LV mass, transmitral peak flow velocity (E), and mitral annular myocardial velocity (Em) were measured. LV mass/volume ratio was calculated. Stroke volume (SV) was measured using aortic diameter and pulsed Doppler velocity profile. SV was indexed for body surface area (SVI). Effective arterial elastance (Ea) was estimated by end-systolic pressure/SVI. End-systolic elastance (Ees) was calculated by a modified single-beat method. End-diastolic elastance (Ed) was calculated from Doppler indices reflective of atrial pressures (E/Em) and the diastolic filling volume (SV). Lipids, uric acid, fasting glucose, insulin, homeostasis model assessment for insulin resistance (HOMA-IR), and high sensitive C-reactive protein (hs-CRP) were also assessed. Results: Ea, Ees, and Ed all increased significantly with BMI(r = 0.30, 0.26, and 0.18, p < 0.01, respectively). There were significant relationships between BMI and non-HDLC, HDLC, uric acid, triglycerides, HOMA-IR, and hs-CRP (r = 0.21, -0.32, 0.48, 0.37, 0.37, 0.52, and 0.39, p < 0.01, respectively). Ea correlated significantly with non-HDLC, HDLC, uric acid, triglycerides, HOMA-IR, and hs-CRP (r = 0.20, -0.15, 0.18, 0.23, 0.22, and 0.14, p < 0.05, respectively). There were significant relationships between Ees and non-HDLC, uric acid, triglycerides, and HOMA-IR (r = 0.25, 0.20, 0.16, and 0.17, p < 0.05, respectively). Ed correlated significantly with non-HDLC (r = 0.18, p < 0.05). In multiple regression analysis, non-HDLC was independent determinants of Ea, Ees, and Ed. Conclusions: Higher non-HDLC and combined arterial-ventricular stiffening may contribute to the increased prevalence of later cardiovascular disorder.