Abstract
Insulin resistance is identified as an impaired biologic response to insulin stimulation of target tissues, primarily the liver, muscle, and adipose tissue. The metabolic consequences of insulin resistance can result in hyperglycemia, hypertension, dyslipidemia, visceral adiposity, hyperuricemia, elevated inflammatory markers, endothelial dysfunction, and a prothrombotic state. Progression of insulin resistance can lead to metabolic syndrome, nonalcoholic fatty liver disease, and type 2 diabetes mellitus. Several techniques are used to measure insulin sensitivity. However, we are in need for easy inexpensive measure. RDW and PDW are numerical measures reported as part of standard compete blood count. To further explore if RDW and PDW could be easy predictors of insulin resistance, we have analyzed in this study the relationship between RDW, PDW and insulin resistance in people with type 2 diabetes with nonalcoholic fatty liver disease.
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