Abstract 13211: Racial Disparities in the Association Between Early Repolarization Pattern and Cardiovascular Mortality

Abstract

Introduction: The early repolarization (ER) ECG pattern has been associated with increased cardiovascular (CV) mortality, but it is unclear if there are racial differences in risk. Objectives: To evaluate racial differences in East Asian and Caucasian decent and the prognostic significance of ER. Methods: A literature search was conducted for studies reporting the association between ER and CV mortality endpoints. The search included the following databases: Ovid MEDLINE, EMBASE, Web of Science, and Google Scholar. The search was not restricted to time or publication status. The minimum follow up duration was one year. Analysis was performed using odd ratios (OR). Results: A total of 16 studies and 189,422 participants (16,307 with ER vs 173,115 without ER) were included; mean follow-up was one year. ER was associated with increased CV mortality (OR 1.68, 95% CI 1.28-2.20; P<0.01). East Asian patients with ER had higher CV mortality compared to Caucasians (OR 3.94, 95% CI 2.2-7.04 vs. OR 1.32, 95% CI 1.03-1.70; P<0.01). (Figure 1-3) Conclusions: ER pattern is associated with increased CV mortality, particularly in East Asian patients.