Abstract
Introduction: Ablation outcomes in persistent atrial fibrillation (AF) are suboptimal. Hypothesis: Characterizing the adenosine effects in non-invasive panoramic mapping can guide ablation to increase long-term freedom of arrhythmias. Methods: Persistent AF patients (N=25, mean±SD: 15.3±8.4 mo) underwent non-invasive panoramic mapping (CardioInsight, Medtronic) twice at baseline (B1 and B2) and then during 12 mg adenosine (Ado) peak effect. Reproducible rotational domains (≥2 rotations) were thereafter ablated (3.2±1.3 sites/patient). Data were exported to determine dominant frequencies (DFs) using short FFT technique with 0.1 Hz resolution and correlation with simultaneous intracardiac recordings (p<0.001). Results: Areas with stable DFs at B1 and B2 (
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