Abstract 13055: Cardiac Structure and Function in US Latinos of Diverse Backgrounds With and Without the Metabolic Syndrome: The Echocardiographic Study of Latinos (Echo-SOL)

Abstract

Background: Hispanics/Latinos with heart failure are younger with more co-morbidities compared to non-Hispanic whites, yet the role of metabolic syndrome (MetS) as a risk factor for cardiac dysfunction in this population has not been well described. Methods: This is a cross-sectional analysis of Echo-SOL, a population-based cohort of 1818 US Hispanics/Latinos. Nondiabetic participants without coronary artery disease or severe valve disease were included. MetS was defined by the AHA/NHLBI 2009 Joint Scientific Statement. Survey multivariable linear regression analyses using sampling weights were used to model the relationship between MetS and echocardiographic measures of cardiac structure and function, adjusting for covariates (age, sex, study site, tobacco use, alcohol use, physical activity, years of education). Additionally, individuals with a body mass index (BMI) <25 without MetS were compared with the following: BMI<25/ +MetS; BMI>25/ -MetS; and BMI>25/+MetS. Results: Among 1260 nondiabetics (59% female) high waist circumference and elevated triglycerides were associated with worse GLS; high waist circumference and elevated blood pressure were associated with higher left ventricular mass index and worse E/E’ ratio. Compared with individuals without MetS, individuals with MetS had lower medial and lateral E’ velocities (-0.4 cm/s, [Standard Error 0.1], p=0.0002; -0.5 cm/s [0.2], p=0.02, respectively), greater E/E’ (0.5 [0.2], p=0.01), and worse 2-chamber global longitudinal strain (GLS) (0.9%, SE 0.3, p=0.009). Individuals with BMI<25/ +MetS (N=22) had the greatest reduction in left ventricular function with worse 4-chamber, 2-chamber and average GLS (2.1% [0.9], p=0.02; 2.3% [0.7], p=0.001; 2.3% [0.7], p=0.002, respectively), reduced medial and lateral E’ velocities (-1.7cm/s [0.4], p<0.0001; -1.6cm/s [0.5, p=0.002], respectively) and lower ejection fraction (-3.5% [1.4], p=0.007) compared with those with a BMI <25 without MetS. Conclusions: In a sample of US Hispanics/Latinos, MetS was associated with worse left ventricular systolic and diastolic function, even among normal weight individuals.