Abstract 12998: Incidence, Complications, and Outcomes of High Degree Atrioventricular Block in Patients With Sarcoidosis

Abstract

Introduction: High degree atrioventricular block (AV block) is known to occur in patients with sarcoidosis. The incidence, complications and outcomes of high degree AVB in sarcoidosis patient is unknown. We aimed to analyze a national database to evaluate the epidemiological characteristics of AVB in sarcoidosis patients. Method: We included 110,264 sarcoidosis adult patients (age ≥18 years) hospitalized in 2019 from the Nationwide Readmission Database (NRD). Baseline demographics, comorbidities, and outcomes were identified using International Classification of Diseases (ICD) codes. High degree AVB was defined as Mobitz type II and complete heart block. Results: Of the total, 2336 (2.1%) sarcoidosis patients (mean age 61.0 ± 14.0 years and 52.8% females) were admitted with AVB. Of these, 71 (3.02%) patients died in the AVB group and 2691(2.49%) in the non AVB group (p >0.05). Complications were noted to be higher in AVB group vs. non AVB group (34.9% vs. 28.5%) but was not significantly associated with AVB (OR 1.03, CI (0.87- 1.23), p=0.7). The commonest complications were acute kidney injury (26.1% vs. 21.4%), cardiac arrest (2.64% vs 0.84%) and device related infection (1.89% vs 0.33%) that were significantly more than non AVB group with p<0.05. The cost of index hospitalization was higher for patients with AVB, but the length of stay was similar. The readmission rates or mortality is not associated with diagnosis of AVB on presentation. Conclusion: In hospitalized sarcoidosis patients, high degree AVB was not associated with increased risk of mortality or readmissions but with higher cost of hospitalization. In these patients, cardiac risk factors were associated with complications.