Abstract 12900: β-Adrenergic Receptor Kinase-1 is Strongly Associated With Physical Heart Failure Symptoms

Abstract

Introduction: Heart failure (HF) is associated with significant physical symptom burden, but exactly how symptoms are related to pathophysiological mechanisms in HF is unclear. To date, no studies have examined the role of metabolic senescence in explaining HF symptoms. Hypothesis: There is a significant relationship between metabolic senescence and physical symptoms among adults with HF. Methods: This was a secondary analysis of data collected from a sample of adults with symptomatic HF. Metabolic senescence was measured with β-adrenergic receptor kinase-1 (βARK1; picograms/milliliter (pg/mL)). Physical symptoms were measured with the HF Somatic Perception Scale (HFSPS; range 0-90, higher = worse). The Seattle HF Model (SHFM) was used as a composite of traditional clinical variables (range roughly 0-4, higher = worse). Generalized linear modeling was used to quantify the relationship between βARK1 and HFSPS scores, adjusting for SHFM scores. Results: The average age of the sample ( n = 96) was 54.3±13.5 years, 77.1% were male, and a majority (83.3%) of the sample had Class III or IV HF. Median raw value of βARK1 was 10.7 (IQR [4.2-28.9]) pg/mL. βARK1 (β = 1.42 ± 0.31, p <0.001) and SHFM scores (β = 12.40 ± 1.58, p < 0.001) were significantly related to HFSPS scores, and there was a significant interaction effect of βARK1 and SHFM scores in predicting HFSPS scores (Figure; interaction effect: β = -0.42 ± 0.09, p < 0.001; model: F (3,88) = 87.00, p < 0.001). In stepwise modeling, βARK1 was significantly associated with HFSPS scores (β = 0.22±0.1, p = 0.038) after controlling for other predictors of physical symptoms (model R 2 = 0.250, F (7, 70) = 3.34, p = 0.004). Conclusions: Worse metabolic senescence is associated with worse physical symptoms in HF, providing preliminary evidence of alternative pathophysiologic mechanisms underlying physical symptoms in HF.