Abstract 12866: Increased Left Ventricular Mass Has Greater Association With Fat Free Mass Than Fat Mass in Black and White Females

Abstract

Introduction: Increased left ventricular mass (LVM) is a risk factor for adult CV disease and is associated with increased body mass including obesity. The effects of different measures of body composition on LVM in young adulthood are not well described. Goals/Aims: Utilizing an existing longitudinal data set of black and white female young adults, we aimed to determine the contribution of various types of body composition measures to increased LVM. Methods: Data from the National Growth and Health Study, a study of racial differences in the development of obesity, including dual energy X-ray absorptiometry (DEXA), MRI, and echocardiogram (collected at ages 24-27) were analyzed. Logistic regression was conducted and receiver-operator characteristic (ROC) curves compared to assess the contribution of fat mass by DEXA (FM), fat-free mass by DEXA (FFM), subcutaneous adipose tissue mass by MRI (SAT), and visceral adipose tissue mass by MRI (VAT) towards the development of LVH (defined as LVMI ≥ 38.6 g/m 2.7 ). Multiple linear regression analyses were performed to assess for contributions to LVMI. Results: 550 women were included in the analysis (52.6% Black, mean age 24.9 ± 0.7 years at baseline). Using logistic regression, FM, FFM, SAT, and VAT were significantly associated with LVH (p < 0.0001 for all), adjusting for SBP, DBP, and race. The ROC for FFM is greater than FM, SAT, and VAT (0.849 vs. 0.832, 0.813, and 0.788 respectively). In linear regression, FFM and DBP were significant contributors to LVMI. Black race was a significant predictor of LVH in the visceral fat model. There were no other significant racial differences. Conclusions: FFM had the greatest association with LVM, confirming previously published data. While the contribution of FFM towards the development of LVH was greater than that of FM and BP, FM and BP are modifiable risk factors and thus targets for clinical intervention.