Abstract 12789: Age-Related Disparities in Complications Among Women With Peripartum Cardiomyopathy

Abstract

Introduction: While the exact pathogenesis of peripartum cardiomyopathy, a potentially life-threatening condition, is still unknown, its incidence is rising globally. We sought to understand the differences in outcomes and complications based on age. Hypothesis: Older women with peripartum cardiomyopathy would have adverse outcomes and complications. Methods: Our study sample consisted of females diagnosed with peripartum cardiomyopathy that required hospitalization care. Records from the 2016-2020 National Inpatient Sample were used for our study. They were divided into two age-based cohorts: 15-29 years and 30-40 years. We evaluated differences in complications between the two groups using multivariable regression. Results: Our analysis consisted of 20520 females diagnosed with peripartum cardiomyopathy, divided as 57.2% in the cohort of ages 30-40 and 42.7% between 15-29 years. Several differences in patient characteristics and comorbidities were noted, as reported in Table 1. Furthermore, patients of ages 30-40 demonstrated higher odds of reporting acute ischemic stroke (aOR 1.354, 95% CI 1.038-1.767, p=0.026) while having a reduced risk of cardiogenic shock (aOR 0.787, 95% CI 0.688-0.901, p<0.01), as compared to those of ages 15-29. No statistically significant differences were noted for events of acute kidney injury (aOR 1.074, 95% CI 0.976-1.182, p=0.143), acute pulmonary edema (aOR 1.147, 95% CI 0.988-1.332, p=0.071), or mortality (aOR 0.978, 95% CI 0.742-1.290, p=0.877) (Table 2). Conclusions: Peripartum cardiomyopathy is a serious condition that requires appropriate care and management. Our study linked cases of ages 30-40 years with increased odds of acute ischemic stroke but lower odds of cardiogenic shock. Physicians should therefore be encouraged to monitor and screen as appropriate to improve outcomes closely.