Abstract 1276: Red meat, poultry, and fish intake, genetic risk variants, and breast cancer risk among Hispanic and non-Hispanic white women: Results from the Breast Cancer Health Disparities Study

Abstract

Abstract Purpose: Breast cancer (BC) incidence rates are lower among US Hispanics compared to non-Hispanic white (NHW) women, and the proportion of Native American (NA) ancestry among Hispanic women is associated with BC risk. Meat intake is inconsistently associated with BC risk, though few studies have included Hispanic women. We investigated: a) the association between various meats and BC risk among Hispanic/NA and NHW women, and b) the potential interaction of meat intake with GWAS-identified risk variants. Methods: The Breast Cancer Health Disparities consortium includes 3 population-based case-control studies conducted in the US and Mexico (N=4410 NHW, N=6163 Hispanic/NA). BC risk factor data and dietary intake were assessed by questionnaires. Five meat variables (gm/day) were harmonized across the 3 studies: red meat, processed red meat, poultry, fish, and tuna. We considered nutrient density variables, created with study-specific cut-points based on intake distribution among controls. Ten GWAS identified SNPs were genotyped, in addition to 104 Ancestry Informative Markers that were used to categorize participants by percent NA ancestry using STRUCTURE (Low: 0-28%; Intermediate: 29-70%; High: >70%). Multivariable logistic regression models were used to estimate odds ratios (ORs) and 95% confidence intervals (CI) of the association between meat variables and BC risk, stratified by menopause status, ethnicity, and, within Hispanics/NA, by percent NA ancestry. Interaction P values were obtained from likelihood ratio tests. Results: Among all women, processed meat was positively associated with pre-menopausal BC risk (Q3 vs. Q1 OR = 1.31; 95% CI = 1.08-1.55; trend p = 0.004; heterogeneity p = 0.027). This association appeared restricted to Hispanic/NA women, albeit a test of heterogeneity by ethnicity was not statistically significant. We also observed a positive association between tuna and BC risk only among pre-menopausal NHW women (Q3 vs. Q1 OR = 1.41; 95% CI = 1.06-1.87; trend p = 0.007; heterogeneity p = 0.007). Among post-menopausal women a positive association between red meat and BC risk only among Hispanic/NA women of low percent NA ancestry (Q3 vs. Q1 OR = 2.06; 95% CI = 1.08-3.91; trend p = 0.037; heterogeneity p = 0.02) was observed. After multiple testing correction marginally significant interactions among NHW women between intake of processed meat and rs3803662-TOX3 (corrected int p = 0.06) and between intake of tuna and rs2067980 (corrected int p = 0.06) were detected. Conclusion: Diets high in processed meats and tuna are associated with elevated BC risk among pre-menopausal Hispanic/NA and NHW women, respectively. Diets high in red meat are associated with elevated BC risk among post-menopausal Hispanic/NA women with low NA ancestry. Citation Format: Andre E. Kim, Mariana C. Stern, Abbie Lundgreen, Juan Pablo Lewinger, Roger K. Wolff, Laura Fejerman, Esther M. John, Gabriela Torres-Mejia, Sue A. Ingles, Avonne E. Connor, Lisa M. Hines, Kathy B. Baumgartner, Anna R. Giuliano, Martha L. Slattery. Red meat, poultry, and fish intake, genetic risk variants, and breast cancer risk among Hispanic and non-Hispanic white women: Results from the Breast Cancer Health Disparities Study. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 1276. doi:10.1158/1538-7445.AM2014-1276