Abstract 12612: Prevalence, Risk Factors and Guideline Directed Medical Therapies Among Premature Peripheral and Coronary Arterial Disease in Large Integrated Healthcare System: Houston Methodist CVD Learning Health System Registry

Abstract

Introduction: Premature coronary artery disease (CAD) and peripheral arterial disease (PAD) are manifestations of accelerated atherothrombotic disease and pose a significant risk for CVD morbidity and mortality. There are scarce insights on prevalence, risk factors, and management practices for these high-risk groups. Methods: In this cross-sectional study, we analyzed patients aged 18-64 y in the Houston Methodist Cardiovascular Disease Learning Health System Registry (n= 1.127 million; June 2016-April 2022). CAD and PAD were identified using ICD 10-CM codes. Results: Among 811,097 individuals (58.6% women and 14.8% NH Blacks, Table ), 2.1% (n=17,094) had premature CAD alone, 0.4% (n=3,243) had isolated premature PAD and 0.2% (n=1,658) had both. Compared to premature CAD alone, patients with isolated premature PAD were more likely to be women, NH Blacks, smokers, and diabetics, with the highest risk burden seen in those with both conditions. Patients with isolated premature PAD had the lowest rates of lipids, HBA1c, and SBP at goals and guideline-directed medical therapies (GDMT) compared to those with premature isolated CAD. Conclusions: Nearly 1 in 40 adults had premature CAD and PAD. Individuals with premature PAD have a more unfavorable CV risk profile and are less likely to achieve risk factor control and receive GDMT. Therefore, system-wide collaborative initiatives for early identification and risk factor optimization for this vulnerable population are warranted.