Abstract 12396: Association of Lipid Profiles With Presence of Aortic Stenosis in Older Adults: Atherosclerosis Risk in Communities Study

Abstract

Introduction: Many risk factors for atherosclerosis are also risk factors for aortic stenosis. We sought to determine if novel and traditional lipid parameters are associated with aortic stenosis in a population-based study. Methods: We conducted a prospective analysis of participants without aortic stenosis at visit 4 (1996-98) of the ARIC Study. We used logistic regression to assess the association between lipoprotein (a) [Lp(a)], remnant-like particle cholesterol (RLP-C), low-density lipoprotein triglycerides (LDL-TG), small dense low-density lipoprotein-cholesterol (sdLDLc), non-high-density lipoprotein-cholesterol (non-HDLc), triglycerides (TG), and low-density lipoprotein-cholesterol (LDL-C) and incident aortic stenosis (defined as peak aortic valve velocity ≥2.0 m/s) on transthoracic echocardiogram (TTE) performed during visits 5 (2011-13) and 7 (2018-19). Results: Our study population included 11,587 individuals (mean age (SD): 76 (5) years, 56% women, 23% Black). 49% and 24.8% had TTE performed at visits 5 and 7 and the presence of aortic stenosis was 5% and 8%, respectively. In adjusted models, LDL-TG, RLP-C, sdLDLc, non-HDLc, TG, and LDLc at visit 4 were associated with aortic stenosis at visit 5. Lp(a) at visit 4 was predictive of aortic stenosis at visit 7 (table). Conclusions: Among persons who survived to old age, novel lipid parameters (including Lp(a), LDL-TG, RLP-C, and sdLDLc) in mid-life were associated with aortic stenosis in late-life. Further studies should determine if lipid-lowering therapies can prevent the development of aortic stenosis.