Abstract 12326: Heart Rate Variability According to Ambulatory Glucose Profile in Patients With Diabetes Mellitus

Abstract

Introduction: Autonomic neuropathy commonly arises as a long-term complication in diabetes mellitus (DM) and can be diagnosed from heart rate variability (HRV), calculated from electrocardiogram (ECG) recordings. Hypothesis: There is limited data about HRV using real-time ECG and ambulatory glucose monitor in patients with diabetes mellitus Methods: Total of 43 patients (66.3±7.5 years) with DM underwent continuous real-time ECG monitor (225.7±107.3 hours) for HRV and ambulatory glucose monitor using remote monitoring system. And we compared HRV according to ambulatory glucose profile . Results: During the monitor, we checked total 15090 times of ECG and ambulatory glucose level simultaneously of all patients. Both time and frequency domain HRV were lower when the patients had poor controlled glucose level (>200mg/dL) as compared with normally controlled glucose levels (<200mg/dL) in Table. In addition, Heart rate and respiration rate increased according to real-time glucose level (P<0.001). Conclusions: Poor controlled glucose level was independently associated with lower HRV in patients with DM. This is further substantiated by independent continuous associations between real-time measures of hyperglycemia and lower HRV. These data strongly suggest that cardiac autonomic dysfunction can be caused by elevated blood sugar alone.