Abstract 12325: Burden of Premature Ventricular Complex is Associated With New-Onset Atrial Fibrillation

Abstract

Introduction: Large burden of premature ventricular complex (PVC)lead to more cardiovascular mortality. A recent nationwide population-based database demonstrated that presence of PVC is associated with increased risk of atrial fibrillation. The relationship between burden of PVC and new onset of atrial fibrillation (AF), however, has never been investigated. Hypothesis: The purpose of the study is to clarify whether burden of PVC is associated with more new-onset AF. Methods: We designed a single-center, retrospective, and large population-based cohort to clarify the role of PVC burden and new-onset atrial fibrillation in Taiwan. PVC patients without history of atrial fibrillation with were divided into low burden group (<1000/day) and moderate to high burden group (≥1000/day) based on the report of 24-h Holter ECG. New-onset AF was defined as new or first detectable events presenting as either persistent or paroxysmal AF. Results: A total of 16030 AF-naïve patients who underwent 24-h Holter ECG were enrolled in this study with a mean follow-up time of 973 days. A propensity-score matched analysis demonstrated moderate to high burden PVC group had a higher risk to have new-onset AF in comparison with low burden (4.96% vs 2.79%, p<0.001). Multivariate Cox regression analysis showed that moderate to high burden of PVC is an independent risk factor to develop new-onset AF. A Kaplan-Meier analysis also showed that patients with moderate to high burden of PVC is associated with more new-onset AF (log rank p<0.001). Conclusions: Burden of PVC is associated with new-onset atrial fibrillation. Patients with moderate to high burden PVC are at a higher risk to have new-onset atrial fibrillation.