Abstract
Introduction: The advance of anticancer therapy increases cardiovascular diseases (CVD) as comorbidity of cancer; however, data regarding cancer comorbidity in CVD patients remains scant. Further, there is a seasonal variation in CVD, but that in CVD with cancer are scarce. Therefore, we examined the trends of yearly prevalence and seasonal variation of CVD with cancer over 9 years using National Database of Health Insurance Claims and Specific Health Checkups of Japan (NDB). Methods: The NDB sampling dataset were randomly sampled 10% from the whole Diagnosis Procedure Combination (DPC) records extracted and anonymized by Ministry of Health, Labour and Welfare in January, April, July and October from 2011 to 2019. We analyzed each disease which required most medical resource in each patient; I110, I500-519 of ICD-10 code as heart failure (HF), I200-249 as acute coronary syndrome (ACS) and I260, 269 as pulmonary thromboembolism (PTE). We defined CVD prevalence as these CVD (HF, ACS and PTE) records divided by total DPC records, and that of CVD with cancer as CVD records, which included any cancer as comorbidity. Seasonal variation was tested by Chi-square test with a Bonferroni correction. Results: Each prevalence of HF, ACS and PTE was increasing (Panel A), decreasing (Panel B) and slightly increasing, respectively. Annual proportions of cancer comorbidity in HF, ACS and PTE were 5.8%, 3.3% and 15.2% and trends of HF and ACS with cancer comorbidity were slightly increasing (Panels D, E), while that of PTE with cancer was not changed. HF, ACS and PTE prevalence were significantly higher in January (winter) than in July (summer); however, the variation of CVD with cancer was diminished (Panels C, F). Conclusions: Cancer comorbidity proportion of HF and ACS have been gradually increased, while that of PTE has not changed for 9 years. Seasonal variation was diminished in CVD with cancer. CVD with cancer is expected to be increasing regardless of season.
Published Version
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