Abstract 1212: Urinary bladder cancer in Sokoto, Northwestern Nigeria: A 10-year histopathological review

Abstract

Abstract Background: Urinary Bladder Cancer is a common disease worldwide. It ranks ninth in cancer incidence and is the 13th leading cause of cancer death among men and women worldwide. The highest incidence is seen usually in developed countries. In our environment, it is the leading cause of cancer and cancer deaths among males because of endemicity of urinary schistosomiasis. Yet, little is done to curb this preventable risk factor of bladder cancer. Objective: The objectives of this study were to describe histopathological pattern of urinary bladder cancer in Sokoto, Northwestern Nigeria. Method: This was a retrospective study of all histologically confirmed cases of bladder cancer seen at the Department of Histopathology, Usmanu Danfodiyo University Teaching Hospital, Sokoto between the years 2006 and 2015. Information was obtained from the database of the Department of Histopathology. The data were validated using Microsoft Excel and exported to SPSS for analysis. The data were analysed for age, sex and histological types using SPSS version 20 software. The results are presented in the form of simple frequency tables and percentages. Results: A total of 190 patients were seen with histologically confirmed bladder cancer out of the 3933 patients with malignancies between the years 2006 and 2015, constituting 4.8% of all malignancies diagnosed in the same period and comprises 160(84.2%) males and 30(15.8%) females with male to female ratio of 5.3:1. Their mean age was 50.8, SD ±14.9 years and range from 1-90 years. The most common bladder cancer was squamous cell carcinoma with 97 (51.1%) cases. 81 (42.6%) patients had urothelial carcinoma, 5(2.6%) were metastatic carcinoma, 4(2.1%) were sarcomatoid carcinoma, 2(1.1%) were rhabdomyosarcoma and only 1(0.5%) case of a signet ring cell carcinoma was recorded. Conclusion: Squamous cell carcinoma remained the most common histological type of bladder cancer in our setting followed by urothelial carcinoma. Preventive measures aim at eradicating urinary schistosomiasis, a predominant and known risk factor of bladder cancer in our environment will go a long way in curtailing the burden of this disease among our people. Citation Format: Saddiku Malami Sahabi, Kabiru Abdullahi. Urinary bladder cancer in Sokoto, Northwestern Nigeria: A 10-year histopathological review [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2018; 2018 Apr 14-18; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2018;78(13 Suppl):Abstract nr 1212.