Abstract
Abstract Accumulating evidences have demonstrated the antineoplastic properties of sulforaphane, a major isothiocyanates present in cruciferous vegetables. However, the natural analogue of sulforaphane, sulforaphene, rich in radish, has yet not been extensively studied for its potential in preventing cancer. In this study, sulforaphene exerted inhibiting effect on migration of SUM159 human breast cancer cells, the migrated cells were reduced from 72.3% in control group to 17.5% in sulforaphene(10uM) treated group. The Hedgehog signaling, known to be involved in cancer invasiveness, was found to be regulated by sulforaphene. The mRNA and protein expression of Gli1 and Smoothened(Smo) which were Hedgehog signaling activating mediators were significantly suppressed by sulforaphene, but the expression of Patched1(Ptch1) an inhibiting mediator, was induced. In addition, the Hedgehog signaling inhibitors, cyclopamine and vismodegib, strongly inhibited the migration of SUM159 breast cancer cells, suggesting the association of Hedgehog signaling with the migration of breast cancer cells. Taken together, sulforaphene significantly inhibited the migration via down-regulating the Hedgehog signaling pathway and suggest that sulforaphene may be considered as a potent phytochemical in suppressing the mammary carcinogenesis. Citation Format: Cheng Bao, Jaehoo Lee, Jiwon Ko, Hyun-Chang Park, Hong jin Lee. Sulforaphene inhibited migration through down-regulating the Hedgehog signaling in SUM159 human breast cancer cells. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 121. doi:10.1158/1538-7445.AM2014-121
Published Version
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