Abstract 12039: Association Between Idiopathic Thrombocytopenic Purpura and Risk of Hemorrhagic Stroke: A Nationwide Inpatient Sample Study

Abstract

Background: Strokes are a major cause of morbidity and mortality worldwide. Low platelet counts are a known risk factor for hemorrhagic stroke, but the association between idiopathic thrombocytopenic purpura (ITP) and different types of strokes remains unclear. Objective: To investigate the impact of ITP on the prevalence of different types of strokes using the Nationwide Inpatient Sample (NIS) database. Methods: We analyzed data from 382,170,108 patients, including 535,602 patients with ITP, from the NIS database. We compared the prevalence of hemorrhagic and non-hemorrhagic strokes between patients with and without ITP. Results: From 2005 to 2014, hemorrhagic stroke occurred in 0.7% to 1.6% of ITP patients compared to 0.4% to 0.6% of patients without ITP. The odds ratio for hemorrhagic stroke in ITP patients was 1.75-2.19, with a statistically significant association in all ten years. Multivariate analysis adjusted for gender, age, race, and hypertension confirmed the positive association between ITP and hemorrhagic stroke across all ten years. Conclusion: Our study provides evidence of a positive association between ITP and hemorrhagic stroke, highlighting the need for increased vigilance in managing patients with ITP. The findings have important implications for clinical practice and suggest the need for further studies to elucidate the mechanisms underlying this association.