Abstract 12026: Correlates of Sleep Disordered Breathing and Cheyne-Stokes Respiration in Patients With Atrial Fibrillation Undergoing Pulmonary Vein Isolation

Abstract

Background: Sleep disordered breathing (SDB) is known as a common comorbidity in patients with atrial fibrillation (AF). Indeed, patients undergoing pulmonary vein isolation (PVI) for AF had a high prevalence of SDB in particular, Cheyne-Stokes respiration (CSR). The aim of the present study is to assess the correlates of SDB severity and CSR in AF patients undergoing PVI. Methods and Results: The study was conducted under a single-center, observational design. We enrolled 140 consecutive patients undergoing PVI. All participants underwent home sleep apnea test (ApneaLink Air, ResMed, Australia) which could determine the severity of SDB as assessed by apnea-hypopnea index (AHI) and the percent of CSR (%CSR) pattern. Overall, 33 (27.9%) patients was no SDB (AHI<5), 53 (37.9%) patients was mild SDB (5≦AHI<15), 33 (23.6%) patients was moderate SDB (15≦AHI<30), and 15 (10.7%) patients was severe SDB(30≦AHI). Correlates of the increased AHI includes male sex (β=0.27, p=0.001), high age (β=0.19, p=0.0028), high body mass index (BMI) (β=0.29, p=0.0013), hypertension (β=0.18, p=0.038), and non-paroxysmal AF (β=0.17, p=0.047). On the other hand, correlates to %CSR rate includes male sex (β=0.17, p=0.026), high age (β=0.22, p=0.0054), non-paroxysmal AF (β=0.27, p=0.0005), high value of HbA1c (β=0.3, p<0.0001), and greater N-terminal fragment of the Brain natriuretic peptide (NT-proBNP) (β=0.26, p=0.0007). Conclusion: Increased SDB severity correlated with male sex, high age, obesity, hypertension and chronicity of AF in patients with PVI. Correlates the percent of %CSR were male sex, high age, the chronicity of AF, high value of HbA1c, and greater NT-proBNP. Treatment for SDB should be consider for these AF patients, because SDB increases the recurrence ratio of AF after PVI.