Abstract 12011: Left Ventricular Hypertrophy Detected by Echocardiogram in Women With HIV

Abstract

Introduction: Left ventricular hypertrophy (LVH) is an independent predictor of major cardiovascular events. People with HIV have an increased risk of cardiovascular disease (CVD), and a higher prevalence of LVH has been reported in this population. Women with HIV (WWH) have a higher CVD risk than their male counterparts. We sought to evaluate the current prevalence and characteristics of LVH in WWH. Methods: We performed a retrospective chart review (n=1,202) of patients seen at the University of Miami/Jackson Memorial Hospital Special Immunology clinic between 2017-2019. Of the 547 charts of WWH, 148 had available transthoracic echocardiogram. Data regarding demographic, clinical, imaging, and laboratory results was obtained. Results: The estimated prevalence of LVH in WWH was 25%. The mean age was 56.2 years. WWH with LVH were significantly older (60.7 vs. 54.9 years old, p=0.002), had higher systolic blood pressure (144 mmHg vs. 132 mmHg, p= 0.031), and left ventricle mass (169.2g vs. 128.7g, p<0.001). Those who had LVH had a higher prevalence of diastolic dysfunction (68.8% vs. 40.3%, p=0.007), diabetes (47.4% vs. 18.7%, p=0.001), hypertension (76.3% vs. 54.2%, p=0.017), heart failure (23.7% vs. 7.5% p=0.012), and CVD (47.4% vs. 24.3%, p=0.008). We found no significant difference in those with and without LVH regarding race, ethnicity, body mass index, ejection fraction, statin use, alcohol use, smoking, or HIV-related factors (CD4 count and an undetectable viral load). Conclusions: These findings suggest that WWH have a higher prevalence of LVH in the current era when compared to previous reports (15% in 2009). Furthermore, consistent with prior reports, WWH with LVH had a higher prevalence of CVD in this cohort. These findings emphasize the need to further assess risk and mechanisms for the development of LVH in WWH to help reduce CVD risk in this population.